Triethylamine → HCID 178473913, compound

HRID 2053799Notes

Reaction equation

HRID 2053799 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[C:22]([OH:24])=O)[C:5]([NH:7][CH2:8][C:9]1[NH:13][C:12]2[CH:14]=[CH:15][C:16]([Cl:18])=[CH:17][C:11]=2[N:10]=1)=[O:6].[C:25]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)(=[O:27])[CH3:26].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N(CC)CC)C>CS(C)=O>[C:25]([N:28]1[CH2:33][CH2:32][N:31]([C:22]([C:21]2[CH:20]=[CH:19][C:4]([C:5]([NH:7][CH2:8][C:9]3[NH:13][C:12]4[CH:14]=[CH:15][C:16]([Cl:18])=[CH:17][C:11]=4[N:10]=3)=[O:6])=[CH:3][C:2]=2[Cl:1])=[O:24])[CH2:30][CH2:29]1)(=[O:27])[CH3:26]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 837951-AcetylpiperazineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 178523088HCID 178523088, compound

Product 1

HCID 178473913HCID 178473913, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Prepared analogously to Example 1d from 3-chloro-N-(5-chloro-1H-benzimidazol-2-ylmethyl)-4-carboxybenzamide, N-acetylpiperazine, TBTU, and triethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 3.13 minutes; C22H21Cl2N5O3 (474.35); mass spectrum: (M+H)+=474.2.

Workup

  1. customHPLC-MS results

Sources & evidence

ORD record
ord-bbba4dfa62b94f1dbd57a45fde220e32
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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