反应详情

A solution of 3-(benzyloxy)-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)-N-(1-isopropyl-1H-pyrazol-3-yl)benzamide (1.97 g, 3.77 mmol) and THF (70 mL) was evacuated and purged with, Argon (×3). Palladium on carbon (10% w/w, 400 mg) was added and reaction mixture was evacuated and finally purged with hydrogen gas. Reaction mixture was left to stir at ambient temperature under hydrogen for 16 hours. Pd/C was filtered off and concentrated in vacuo to give the product as a colourless oil (1.58 g, 97%).

1. custompurged with, Argon (×3)
2. additionPalladium on carbon (10% w/w, 400 mg) was added
3. customreaction mixture
4. customwas evacuated
5. customfinally purged with hydrogen gas
6. customReaction mixture
7. waitwas left
8. filtrationPd/C was filtered off
9. concentrationconcentrated in vacuo