Trifluoroacetic acid → HCID 178427101, compound

HRID 2053851Notes

Reaction equation

HRID 2053851 reaction equation
C(OC([NH:8][CH2:9][CH:10]([NH:21][C:22](=[O:37])[C:23]1[CH:28]=[CH:27][C:26]([C:29]([N:31]2[CH2:35][CH2:34][CH2:33][CH2:32]2)=[O:30])=[C:25]([CH3:36])[CH:24]=1)[C:11]1[NH:15][C:14]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:13]=2[N:12]=1)=O)(C)(C)C.FC(F)(F)C(O)=O.ClCl>>[NH2:8][CH2:9][CH:10]([NH:21][C:22](=[O:37])[C:23]1[CH:28]=[CH:27][C:26]([C:29]([N:31]2[CH2:35][CH2:34][CH2:33][CH2:32]2)=[O:30])=[C:25]([CH3:36])[CH:24]=1)[C:11]1[NH:15][C:14]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:13]=2[N:12]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 24526ChlorineHCID 178427103HCID 178427103, compound

Product 1

HCID 178427101HCID 178427101, compoundYield 60%

Procedure

Prepared analogously to Example 17 from rac.-N-[2-tert-butoxycarbonylamino-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide and trifluoroacetic acid. Yield: 60%; C22H24ClN5O2 (425.92); mass spectrum: (M+H)+=426/428 (chlorine isotope).

Sources & evidence

ORD record
ord-e3f813f2f1ee47568050281c44a60912
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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