Sodium Chloride → HCID 178474790, compound

HRID 2053893Notes

Reaction equation

HRID 2053893 reaction equation
[NH2:1][CH2:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]([C:11]1[CH:31]=[CH:30][C:14]([C:15]([NH:17][C@H:18]([C:20]2[NH:24][C:23]3[CH:25]=[CH:26][C:27]([Cl:29])=[CH:28][C:22]=3[N:21]=2)[CH3:19])=[O:16])=[CH:13][C:12]=1[Cl:32])=[O:10].[C:33](OC(=O)C)(=[O:35])[CH3:34].[Cl-].[Na+].ClCl>C(O)(=O)C.CO>[C:33]([NH:1][CH2:2][CH2:3][C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9]([C:11]1[CH:31]=[CH:30][C:14]([C:15]([NH:17][C@H:18]([C:20]2[NH:24][C:23]3[CH:25]=[CH:26][C:27]([Cl:29])=[CH:28][C:22]=3[N:21]=2)[CH3:19])=[O:16])=[CH:13][C:12]=1[Cl:32])=[O:10])(=[O:35])[CH3:34]

Participants

7

Reactant 4

HCID 5234Sodium ChlorideHCID 7918Acetic AnhydrideHCID 24526ChlorineHCID 178462063HCID 178462063, compound

Product 1

HCID 178474790HCID 178474790, compoundYield 67%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 887MethanolSolvent

Procedure

Prepared analogously to Example 124 from 4-[(2S)-2-(2-aminoethyl)pyrrolidin-1-ylcarbonyl]-3-chloro-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]benzamide and acetic anhydride in glacial acetic acid. Yield: 67%; Rf value: 0.32 (Reversed phase RP 8; methanol:5% sodium chloride solution=6:4); C25H27Cl2N5O3 (516.43); mass spectrum: (M+H)+=516/518/520 (chlorine isotope).

Sources & evidence

ORD record
ord-75465f0829b84c99a502588ea8a476b7
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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