HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → HCID 178474790, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178462063 | HCID 178462063 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178474790 | HCID 178474790 | 67% |
Reaction Steps
Prepared analogously to Example 124 from 4-[(2S)-2-(2-aminoethyl)pyrrolidin-1-ylcarbonyl]-3-chloro-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]benzamide and acetic anhydride in glacial acetic acid. Yield: 67%; Rf value: 0.32 (Reversed phase RP 8; methanol:5% sodium chloride solution=6:4); C25H27Cl2N5O3 (516.43); mass spectrum: (M+H)+=516/518/520 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-75465f0829b84c99a502588ea8a476b7 |
| Source note | uspto-grants-2008_02 |