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HRID2053896

反应详情

EQUATION

反应方程式

HRID 2053896 的结构方程式

REACTANTS

反应物

4
结构：ClCl
HCID24526

Chlorine

Cl2

结构：C[Si](C)(C)I
HCID85247

Silane, iodotrimethyl-

C3H9ISi

结构：CCO.ClCCl
HCID21584144

Dichloromethane ethanol

C3H8Cl2O

结构：Cc1cc(C(=O)N[C@@H](CCNC(=O)OCc2ccccc2)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1
HCID178427189

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C(=O)N[C@@H](CCN)c2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1
HCID178427186

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Prepared analogously to Example 94 from N-[(1S)-3-(benzyloxycarbonylamino)-1-(5-chloro-1H-benzimidazol-2-yl)propyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide and iodotrimethylsilane in dichloromethane. Yield: quantitative; Rf value: 0.25 (silica gel; dichloromethane/ethanol=4:1); C23H26ClN5O2 (439.94); mass spectrum: (M+H)+=440/442 (chlorine isotope).