HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427186, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Trimethylsilyl iodide | HCID 85247 | — |
| Reactant | Dichloromethane ethanol | HCID 21584144 | — |
| Reactant | N-[(1S)-3-(benzyloxycarbonylamino)-1-(5-chloro-1H-benzimidazol-2-yl)propyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide | HCID 178427189 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178427186 | HCID 178427186 | — |
Reaction Steps
Prepared analogously to Example 94 from N-[(1S)-3-(benzyloxycarbonylamino)-1-(5-chloro-1H-benzimidazol-2-yl)propyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide and iodotrimethylsilane in dichloromethane. Yield: quantitative; Rf value: 0.25 (silica gel; dichloromethane/ethanol=4:1); C23H26ClN5O2 (439.94); mass spectrum: (M+H)+=440/442 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-2e8f3cde28064d1580ff69e63896acc2 |
| Source note | uspto-grants-2008_02 |