HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 178477625, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | HCID 178477439 | HCID 178477439 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178477625 | HCID 178477625 | 97% |
Reaction Steps
Prepared analogously to Example 85 from 3-chloro-N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-(ethylsulfanyl)ethyl]-4-(pyrrolidin-1-ylcarbonyl)benzamide, 3-chloroperoxybenzoic acid, and glacial acetic acid in dichloromethane. Yield: 97%; Rf value: 0.31 (silica gel; dichloromethane/ethanol=9:1); C23H24C12N4O3S (507.44); mass spectrum: (M+H)+=507/509/511 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-bdf6292b985b4ac3ac9be56c2a677666 |
| Source note | uspto-grants-2008_02 |