huagongshe.com
HRID2053906

反应详情

EQUATION

反应方程式

HRID 2053906 的结构方程式

REACTANTS

反应物

4
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：ClCl
HCID24526

Chlorine

Cl2

结构：O=C(OO)c1cccc(Cl)c1
HCID70297

Benzenecarboperoxoic acid, 3-chloro-

C7H5ClO3

结构：CCSC[C@H](NC(=O)c1ccc(C(=O)N2CCCC2)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
HCID178477439

未命名化合物

PRODUCTS

生成物

1
结构：CCS(=O)C[C@H](NC(=O)c1ccc(C(=O)N2CCCC2)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1
HCID178477625

未命名化合物

收率 97%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 85 from 3-chloro-N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-(ethylsulfanyl)ethyl]-4-(pyrrolidin-1-ylcarbonyl)benzamide, 3-chloroperoxybenzoic acid, and glacial acetic acid in dichloromethane. Yield: 97%; Rf value: 0.31 (silica gel; dichloromethane/ethanol=9:1); C23H24C12N4O3S (507.44); mass spectrum: (M+H)+=507/509/511 (chlorine isotope).