HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 178523887, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Chloro-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 69315164 | — |
| Reactant | HCID 178511833 | HCID 178511833 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178523887 | HCID 178523887 | 20% |
Reaction Steps
Prepared analogously to Example 1g from 3-chloro-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, N-methylmorpholine, and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-hydroxyethylamine in N,N-dimethylformamide. Yield: 20%; Rf value: 0.6 (silica gel; dichloromethane/methanol=95:5); C21H18Cl2N4O3 (445.31); mass spectrum: (M+H)+=445/447/449 (chlorine isotope) and (M+H)−=443/445/447 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-87bec47cf32d4784aa5b1a2d0276864b |
| Source note | uspto-grants-2008_02 |