反应详情

Prepared analogously to Example 1g from 3-chloro-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, N-methylmorpholine, and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-hydroxyethylamine in N,N-dimethylformamide. Yield: 20%; Rf value: 0.6 (silica gel; dichloromethane/methanol=95:5); C21H18Cl2N4O3 (445.31); mass spectrum: (M+H)+=445/447/449 (chlorine isotope) and (M+H)−=443/445/447 (chlorine isotope).