Diethyl Ether → HCID 69314856, compound

HRID 2053949Notes

Reaction equation

HRID 2053949 reaction equation
[NH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13])[NH2:2].O=[C:17]([CH:23]1[CH2:27][CH2:26][CH2:25][C:24]1=O)[C:18]([O:20][CH2:21][CH3:22])=[O:19].C(OCC)C>C(O)(=O)C>[CH2:21]([O:20][C:18]([C:17]1[C:23]2[CH2:27][CH2:26][CH2:25][C:24]=2[N:1]([C:3]2[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][C:4]=2[C:12]([F:13])([F:14])[F:15])[N:2]=1)=[O:19])[CH3:22]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 252487ethyl 2-oxo-2-(2-oxocyclopentyl)acetateHCID 69309751HCID 69309751, compound

Product 1

HCID 69314856HCID 69314856, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4.0 g (18.2 mmol) of 4-hydrazino-3-trifluoromethylbenzoic acid is dissolved in 20 mL of glacial acetic acid, combined with 3.3 g (18.2 mmol) of ethyl oxo-(2-oxocyclopentyl)acetate, and refluxed for 2 hours under a nitrogen atmosphere. After cooling, it is stirred with diethyl ether and the precipitate is suction filtered. Yield: 2.9 g (43%).

Workup

  1. temperaturerefluxed for 2 hours under a nitrogen atmosphere
  2. temperatureAfter cooling
  3. filtrationfiltered

Sources & evidence

ORD record
ord-9c8392d6b49440d094d5b51d738cbd7d
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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