Sulfuric Acid → HCID 86620554, compound

HRID 2053952Notes

Reaction equation

HRID 2053952 reaction equation
S(=O)(=O)(O)O.C[O:7][CH:8](OC)[C:9]1[C:13]2[CH2:14][CH2:15][CH2:16][C:12]=2[N:11]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][C:18]=2[C:25]([F:28])([F:27])[F:26])[N:10]=1>ClCCl>[CH:8]([C:9]1[C:13]2[CH2:14][CH2:15][CH2:16][C:12]=2[N:11]([C:17]2[CH:24]=[CH:23][C:20]([C:21]#[N:22])=[CH:19][C:18]=2[C:25]([F:28])([F:26])[F:27])[N:10]=1)=[O:7]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 69311309HCID 69311309, compound

Product 1

HCID 86620554HCID 86620554, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

4.7 mL (12.2 mmol) of sulfuric acid is added dropwise with stirring to a suspension of 32 g of silica gel in 175 mL of dichloromethane. Then 4.3 g (12.2 mmol) of 4-(3-dimethoxymethyl-5,6-dihydro-4H-cyclopentapyrazol-1-yl)-3-trifluoromethylbenzonitrile in 75 mL of dichloromethane is added and the mixture is stirred for 20 hours at ambient temperature. The silica gel is filtered off and the solution is concentrated. Yield: 3.7 g (99%).

Workup

  1. filtrationThe silica gel is filtered off
  2. concentrationthe solution is concentrated

Sources & evidence

ORD record
ord-a257a8a588004ab0a0e070ecf0f257c6
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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