Sulfuric Acid → HCID 86620554, compound

Participants

Reaction Steps

4.7 mL (12.2 mmol) of sulfuric acid is added dropwise with stirring to a suspension of 32 g of silica gel in 175 mL of dichloromethane. Then 4.3 g (12.2 mmol) of 4-(3-dimethoxymethyl-5,6-dihydro-4H-cyclopentapyrazol-1-yl)-3-trifluoromethylbenzonitrile in 75 mL of dichloromethane is added and the mixture is stirred for 20 hours at ambient temperature. The silica gel is filtered off and the solution is concentrated. Yield: 3.7 g (99%).

Provenance & Evidence