Chlorine → HCID 178498064, compound

HRID 2053975Notes

Reaction equation

HRID 2053975 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([C:11]([NH:13][CH:14]([C:16]2[NH:20][C:19]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:18]=3[N:17]=2)[CH3:15])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH3:26][O:27][C:28]([CH:30]1[CH2:34][CH2:33][CH2:32][NH:31]1)=[O:29].C(N(C(C)C)CC)(C)C.ClCl>CS(C)=O>[Cl:1][C:2]1[CH:10]=[C:9]([CH:8]=[CH:7][C:3]=1[C:4]([N:31]1[CH2:32][CH2:33][CH2:34][CH:30]1[C:28]([O:27][CH3:26])=[O:29])=[O:5])[C:11]([NH:13][CH:14]([C:16]1[NH:20][C:19]2[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:18]=2[N:17]=1)[CH3:15])=[O:12]

Participants

6

Reactant 4

HCID 24526ChlorineHCID 81531DiisopropylethylamineHCID 94239Methyl DL-prolinateHCID 178464831HCID 178464831, compound

Product 1

HCID 178498064HCID 178498064, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Prepared analogously to Example 1d from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, rac.-2-(methyloxycarbonyl)pyrrolidine, PFTU, and diisopropylethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 4.30 minutes; C23H22C12N4O4 (489.36); mass spectrum: (M−H)−=488/490/492 (chlorine isotope).

Workup

  1. customHPLC-MS results

Sources & evidence

ORD record
ord-3f101ecfca14426db8ed971f3254ee1d
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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