HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → Rac.-3-chloro-n-[1-(5-chloro-1h-benzimidazol-2-yl)ethyl]-4-[3-(2,2,2-trifluoroacetylamino)pyrrolidin-1-ylcarbonyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,2,2-Trifluoro-N-(pyrrolidin-3-YL)acetamide | HCID 537575 | — |
| Reactant | HCID 178464831 | HCID 178464831 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Rac.-3-chloro-n-[1-(5-chloro-1h-benzimidazol-2-yl)ethyl]-4-[3-(2,2,2-trifluoroacetylamino)pyrrolidin-1-ylcarbonyl]benzamide | HCID 178464812 | — |
Reaction Steps
Prepared analogously to Example 1d from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, 3-(2,2,2-trifluoroacetylamino)pyrrolidine, PFTU, and diisopropylethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 4.34 minutes; C23H20Cl2F3N5O3 (542.34); mass spectrum: (M−H)−=541/543/545 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-f53cfa2108744753ad7d027e81cfc0eb |
| Source note | uspto-grants-2008_02 |