HRID2053995

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24526

Chlorine

Cl2

HCID81531

Diisopropylethylamine

C8H19N

HCID537575

2,2,2-Trifluoro-N-(pyrrolidin-3-YL)acetamide

C6H9F3N2O

结构：CC(NC(=O)c1ccc(C(=O)O)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1

HCID178464831

未命名化合物

PRODUCTS

生成物

结构：CC(NC(=O)c1ccc(C(=O)N2CCC(NC(=O)C(F)(F)F)C2)c(Cl)c1)c1nc2cc(Cl)ccc2[nH]1

HCID178464812

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

PROCEDURE

实验过程

Prepared analogously to Example 1d from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, 3-(2,2,2-trifluoroacetylamino)pyrrolidine, PFTU, and diisopropylethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 4.34 minutes; C23H20Cl2F3N5O3 (542.34); mass spectrum: (M−H)−=541/543/545 (chlorine isotope).

WORKUP

后处理

customHPLC-MS results