HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylpyridine → 2-Pyridin-2-yl-4-trifluoromethyl-imidazo[1,5-a]pyrimidine-8-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylpyridine | HCID 14286 | — |
| Reactant | 5-amino-1H-imidazole-4-carbonitrile | HCID 78777 | — |
| Reactant | 4,4,4-Trifluoro-1-(pyridin-2-yl)butane-1,3-dione | HCID 2771478 | — |
| Product | 2-Pyridin-2-yl-4-trifluoromethyl-imidazo[1,5-a]pyrimidine-8-carbonitrile | HCID 67213352 | 47% |
Reaction Steps
Reaction of 1-pyridin-2-yl-4,4,4-trifluoro-butane-1,3-dione (217 mg, 1.0 mmol), prepared from commercially available 2-acetylpyridine according to general procedure A, and 4-amino-5-cyano-1H-imidazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (135 mg, 47%). MS (ISP) 289.9 [(M+H)+]; mp 205° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329662B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-a09147441c5b43728e8271431cf7dfe3 |
| Source note | uspto-grants-2008_02 |