Hydrazine hydrate (1:1) → HCID 11185412, compound

HRID 2054344Notes

Reaction equation

HRID 2054344 reaction equation
NCC(C1NC2C(C=1)=CC=CN=2)OC1CCCCO1.[CH3:20][O:21][C:22]1[CH:30]=[CH:29][N:28]=[C:27]2[C:23]=1[CH:24]=[C:25]([CH:31]([O:44][CH:45]1[CH2:50][CH2:49][CH2:48][CH2:47][O:46]1)[CH2:32][N:33]1C(=O)C3=CC=CC=C3C1=O)[NH:26]2.NN.O>CCO>[NH2:33][CH2:32][CH:31]([C:25]1[NH:26][C:27]2[C:23]([CH:24]=1)=[C:22]([O:21][CH3:20])[CH:30]=[CH:29][N:28]=2)[O:44][CH:45]1[CH2:50][CH2:49][CH2:48][CH2:47][O:46]1

Participants

5

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 11379978HCID 11379978, compoundHCID 59655786HCID 59655786, compound

Product 1

HCID 11185412HCID 11185412, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the same procedure as for 9a. From 4-Methoxy-2-[2-phthalimido-1-(2,3,5,6-tetrahydropyran-2-yl)oxyethyl]-7-azaindole (2.9 g, 10 mmol) in EtOH (100 ml) and NH2NH2.H2O (420 μl, 15 mmol). After a reaction time of 3 h. a diastereomeric mixture (1:1) of 9b (1.9 g, 95%) was obtained.

Sources & evidence

ORD record
ord-83f2f7d3401e41e09913a38be71acaa2
Source dataset
uspto-grants-2008_02
Patent number
US07329666B2

Reaction notes

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