Dichloromethane → HCID 11401184, compound

HRID 2054350Notes

Reaction equation

HRID 2054350 reaction equation
O[CH:2]1[CH2:7][NH:6][C:5](=[O:8])[N:4]2[C:9]3[N:15]=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=[C:3]12.C(Cl)Cl>>[N:15]1[C:9]2[N:4]3[C:5](=[O:8])[NH:6][CH:7]=[CH:2][C:3]3=[CH:11][C:10]=2[CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 21575571HCID 21575571, compound

Product 1

HCID 11401184HCID 11401184, compoundYield 95%

Procedure

To a cooled (0° C.) solution of 6,7,8,9-Tetrahydro-6-hydroxypyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidin-9-one (1 g, 4.2 mmol) and TEA (1.74 ml, 13 mmol) in CH2Cl2 (200 ml) MsCl (320 μl, 4.2 mmol) was dropwise added. The reaction mixture was stirred for 30 min. at the same temperature and the organic solution was washed with saturated aq. NH4Cl and with water. The organic solution was dried and evaporated to obtain 11a (730 mg, 95%), as a white solid without further purification

Workup

  1. additionwas dropwise added
  2. washthe organic solution was washed with saturated aq. NH4Cl and with water
  3. customThe organic solution was dried
  4. customevaporated

Sources & evidence

ORD record
ord-ee9892ff29b54ceca190f13543d9d85f
Source dataset
uspto-grants-2008_02
Patent number
US07329666B2

Reaction notes

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