Dichloromethane → HCID 11401184, compound

Participants

Reaction Steps

To a cooled (0° C.) solution of 6,7,8,9-Tetrahydro-6-hydroxypyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidin-9-one (1 g, 4.2 mmol) and TEA (1.74 ml, 13 mmol) in CH2Cl2 (200 ml) MsCl (320 μl, 4.2 mmol) was dropwise added. The reaction mixture was stirred for 30 min. at the same temperature and the organic solution was washed with saturated aq. NH4Cl and with water. The organic solution was dried and evaporated to obtain 11a (730 mg, 95%), as a white solid without further purification

Provenance & Evidence