N-Iodosuccinimide → HCID 11236615, compound

HRID 2054360Notes

Reaction equation

HRID 2054360 reaction equation
[S:1]([NH:11][C:12]1[N:17]2[C:18]3[N:24]=[CH:23][CH:22]=[CH:21][C:19]=3[CH:20]=[C:16]2[CH:15]=[CH:14][N:13]=1)([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)(=[O:3])=[O:2].[I:25]N1C(=O)CCC1=O>C(Cl)Cl>[I:25][C:20]1[C:19]2[CH:21]=[CH:22][CH:23]=[N:24][C:18]=2[N:17]2[C:16]=1[CH:15]=[CH:14][N:13]=[C:12]2[NH:11][S:1]([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)(=[O:2])=[O:3]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 11267733HCID 11267733, compound

Product 1

HCID 11236615HCID 11236615, compoundYield 100.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 23a (10 mg, 0.03 mmol) in CH2Cl2 (5 ml) at −30° C. N-iodosuccinimide (7 mg mg, 0.03 mmol) was portionwise added and the mixture was stirred for 15 min. The solution was washed with water and the organic solutions was dried, filtered and evaporated to obtain 24a (14 mg, 95%) as a yellow solid.

Workup

  1. customat −30° C
  2. washThe solution was washed with water
  3. customthe organic solutions was dried
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-9e16f87dba3b40389041552b7b0747db
Source dataset
uspto-grants-2008_02
Patent number
US07329666B2

Reaction notes

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