反应详情

790 mg of (±)-acetic acid (1RS,3RS,4RS)-4-amino-3-3,4-dimethoxyphenyl)cyclohexyl ester (compound B1), 620 mg of 4-butoxybenzoic acid, 614 mg of N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride and 2 mg of 4-dimethylaminopyridine are stirred in 7 ml of dichloromethane for 18 h. 5 ml of water are added, the phases are separated and once the organic layer is extracted with 3 ml of dichloromethane. Then the organic layer is washed with 2.5 ml of saturated aqueous potassium bicarbonate solution and the aqueous solution is once extracted with 5 ml of dichloromethane. The combined organic layers are dried over magnesium sulfate, then the solvent is removed to give 1172 mg of the title compound as a colorless foam.

1. customthe phases are separated
2. extractiononce the organic layer is extracted with 3 ml of dichloromethane
3. washThen the organic layer is washed with 2.5 ml of saturated aqueous potassium bicarbonate solution
4. extractionthe aqueous solution is once extracted with 5 ml of dichloromethane
5. dry with materialThe combined organic layers are dried over magnesium sulfate
6. customthe solvent is removed