HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2054543Generated: October 30, 2026
hydroxylamine-O-sulfonic acid → 3-Bromo-5-methylthiophene-2-carbonitrile
https://huagongshe.com/reaction/2054543
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | hydroxylamine-O-sulfonic acid | HCID 76284 | — |
| Reactant | 3-Bromo-5-methylthiophene-2-carbaldehyde | HCID 818885 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Bromo-5-methylthiophene-2-carbonitrile | HCID 69107988 | 83.2% |
Reaction Steps
To a suspension of 3-bromo-5-methyl-2-thiophenecarboxaldehyde (500 mg) in water (10 ml) was added hydroxylamine-O-sulfonic acid (330 mg). The mixture was heated to 50° C. for 12 h and allowed to cool. The mixture was then extracted with ethyl acetate (3×50 ml). The combined organic layers were washed (brine), dried (MgSO4), filtered and evaporated to leave the sub-title compound (410 mg) as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07329686B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-203885634b22458bb48375919679ef63 |
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| Source note | uspto-grants-2008_02 |
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