反应详情

温度

50 °C

To a suspension of 3-bromo-5-methyl-2-thiophenecarboxaldehyde (500 mg) in water (10 ml) was added hydroxylamine-O-sulfonic acid (330 mg). The mixture was heated to 50° C. for 12 h and allowed to cool. The mixture was then extracted with ethyl acetate (3×50 ml). The combined organic layers were washed (brine), dried (MgSO4), filtered and evaporated to leave the sub-title compound (410 mg) as a brown solid.

1. temperatureto cool
2. extractionThe mixture was then extracted with ethyl acetate (3×50 ml)
3. washThe combined organic layers were washed (brine)
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customevaporated