Pyridine → HCID 3004969, compound

HRID 2054551Notes

Reaction equation

HRID 2054551 reaction equation
N1C=CC=CC=1.[C:7]12([C:17](Cl)=[O:18])[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][CH:9]([CH2:10]3)[CH2:8]1)[CH2:14]2.[C:20]1([NH:26][C:27](=[S:30])[NH:28][NH2:29])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(Cl)Cl>[C:7]12([C:17]([NH:29][NH:28][C:27]([NH:26][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[S:30])=[O:18])[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][CH:9]([CH2:10]3)[CH2:8]1)[CH2:14]2

Participants

5

Reactant 3

HCID 1049PyridineHCID 989151-Adamantanecarbonyl chlorideHCID 730679Hydrazinecarbothioamide, N-phenyl-

Product 1

HCID 3004969HCID 3004969, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Pyridine (0.808 mL, 10 mmol) was added dropwise at room temperature to a stirred solution of 1-adamantanecarbonyl choride (A) (1 g, 5 mmol) and 4-phenyl-3-thiosemicarbazide (B) (0.845 g, 5.05 mmol) in CH2Cl2 (10 mL). After stirring for 4 h, the solvent was removed in vacuo, and the residue washed with water and dried to give 1-(1-adamantylcarbonyl)-4-phenyl thiosemicarbazide (C).

Workup

  1. customthe solvent was removed in vacuo
  2. washthe residue washed with water
  3. customdried

Sources & evidence

ORD record
ord-de3ff8c1095744d1a745daaffa8036aa
Source dataset
uspto-grants-2008_02
Patent number
US07329683B2

Reaction notes

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