反应详情

温度

120 °C

5.4 g of 3-fluoro-4-nitrophenol and 4.3 ml of 3,5-dimethylaniline were mixed and stirred for 6 hours at 120° C. After cooling, it was taken up in ethyl acetate and water and extracted three times with 1N aqueous hydrochloric acid. The combined aqueous phases were extracted three times with ethyl acetate. The combined organic phases were dried on sodium sulfate, concentrated by evaporation in a vacuum, and the residue was crystallized.

1. temperatureAfter cooling
2. extractionwater and extracted three times with 1N aqueous hydrochloric acid
3. extractionThe combined aqueous phases were extracted three times with ethyl acetate
4. customThe combined organic phases were dried on sodium sulfate
5. concentrationconcentrated by evaporation in a vacuum
6. customthe residue was crystallized