P-Anisidine → HCID 21937979, compound

HRID 2054631Notes

Reaction equation

HRID 2054631 reaction equation
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=1>ClCCl>[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:2]2[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 7732P-AnisidineHCID 5209483-Fluoro-4-nitrophenol

Product 1

HCID 21937979HCID 21937979, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
150 °C

Procedure

0.16 g of 3-fluoro-4-nitrophenol and 0.37 g of p-anisidine were mixed and stirred for 1.5 hours at 150° C. After cooling, it was dissolved in dichloromethane, and extracted twice with 1N aqueous hydrochloric acid and once with saturated sodium chloride solution. The organic phase was dried on sodium sulfate and concentrated by evaporation in a vacuum.

Workup

  1. temperatureAfter cooling
  2. extractionextracted twice with 1N aqueous hydrochloric acid and once with saturated sodium chloride solution
  3. customThe organic phase was dried on sodium sulfate
  4. concentrationconcentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-6cb020c80e4d41c2ab9910463de69f0f
Source dataset
uspto-grants-2008_02
Patent number
US07329679B2

Reaction notes

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