Sodium Hydroxide → 5-Fluoro-2,4-dinitrophenol

HRID 2054641Notes

Reaction equation

HRID 2054641 reaction equation
[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4](F)[CH:3]=1.[OH-:15].[Na+]>O>[F:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([OH:15])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 675981,5-Difluoro-2,4-dinitrobenzene

Product 1

HCID 150838855-Fluoro-2,4-dinitrophenol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.41 g of 1,3-difluoro-4,6-dinitrobenzene was dissolved in 8 ml of 0.5 N aqueous sodium hydroxide solution and refluxed for 2 hours. After cooling, it was diluted with water and extracted three times with diethyl ether. The aqueous phase was made acidic by adding 1N hydrochloric acid and extracted with diethyl ether. The organic phase was dried on sodium sulfate and concentrated by evaporation in a vacuum.

Workup

  1. temperaturerefluxed for 2 hours
  2. temperatureAfter cooling
  3. extractionextracted three times with diethyl ether
  4. additionby adding 1N hydrochloric acid
  5. extractionextracted with diethyl ether
  6. customThe organic phase was dried on sodium sulfate
  7. concentrationconcentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-c6537bed28614d2da777b036950746fd
Source dataset
uspto-grants-2008_02
Patent number
US07329679B2

Reaction notes

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