反应详情

温度

80 °C

1 g of 1,2-diphenyl-6-methyl-1H-benzimidazole was suspended in 31 ml of 40% sulfuric acid and mixed with 13.5 g of cerium ammonium nitrate. It was allowed to stir for 2.5 hours at 80° C., cooled to 20° C., and carefully stirred into saturated aqueous sodium bicarbonate solution. The mixture was extracted three times with ethyl acetate, the combined extracts were washed with saturated aqueous sodium chloride solution, dried on sodium sulfate solution and evaporated to the dry state in a vacuum. The residue was chromatographed on silica gel.

1. temperaturecooled to 20° C.
2. extractionThe mixture was extracted three times with ethyl acetate
3. washthe combined extracts were washed with saturated aqueous sodium chloride solution
4. customdried on sodium sulfate solution
5. customevaporated to the dry state in a vacuum
6. customThe residue was chromatographed on silica gel