Hydrogen Bromide → HCID 21938168, compound

HRID 2054662Notes

Reaction equation

HRID 2054662 reaction equation
[Br:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:7]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[C:6]=2[CH:5]=[C:4]([O:24]C)[CH:3]=1.Br>C(O)(=O)C>[Br:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:7]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=3)[C:6]=2[CH:5]=[C:4]([OH:24])[CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 21938149HCID 21938149, compound

Product 1

HCID 21938168HCID 21938168, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1.2 g of 4-bromo-6-methoxy-1-(4-methylphenyl)-2-phenyl-1H-benzimidazole, 6 ml of acetic acid and 6 ml of aqueous hydrobromic acid (62%) are boiled for 5.5 hours. Then, it is precipitated with water, and the precipitate is suctioned off. The latter was then dispersed between ethyl acetate and 2N sodium hydroxide solution. After the organic phase was washed with water, it was concentrated by evaporation.

Workup

  1. customThen, it is precipitated with water
  2. additionThe latter was then dispersed between ethyl acetate and 2N sodium hydroxide solution
  3. washAfter the organic phase was washed with water, it
  4. concentrationwas concentrated by evaporation

Sources & evidence

ORD record
ord-72eab937d6bb4cddabef618c2c4676c8
Source dataset
uspto-grants-2008_02
Patent number
US07329679B2

Reaction notes

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