HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine → (2S)-4-(5-chloro-2-fluorophenyl)-2-(3-hydroxyphenyl)-1-(2-methylalanyl)-2,5-dihydro-1H-pyrrole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | 4-(5-chloro-2-fluorophenyl)-2-(3-hydroxyphenyl)-1-(2-methylalanyl)-2,5-dihydro-1H-pyrrole | HCID 59656602 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2S)-4-(5-chloro-2-fluorophenyl)-2-(3-hydroxyphenyl)-1-(2-methylalanyl)-2,5-dihydro-1H-pyrrole | HCID 58641415 | — |
Reaction Steps
Resolution of enantiomers of racemic 4-(5-chloro-2-fluorophenyl)-2-(3-hydroxyphenyl)-1-(2-methylalanyl)-2,5-dihydro-1H-pyrrole (3-4) by chiral normal-phase BPLC (Chiralcel OD column: 0.1% diethylamine in 10% ethanol in hexanes initially, grading to 30% ethanol in hexanes) provided (2S)-4-(5-chloro-2-fluorophenyl)-2(3-hydoxyphenyl)-1-(2-methylalanyl)-2,5-dihydro-1H-pyrrole (3-5) as the first eluting, minus (−) enantiomer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329762B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-b2d13acffcce46dbb3de959c6c0e2aea |
| Source note | uspto-grants-2008_02 |