HRID2054752

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8021

Diethylamine

C4H11N

结构：CC(C)(N)C(=O)N1CC(c2cc(Cl)ccc2F)=CC1c1cccc(O)c1

HCID59656602

未命名化合物

PRODUCTS

生成物

结构：CC(C)(N)C(=O)N1CC(c2cc(Cl)ccc2F)=C[C@H]1c1cccc(O)c1

HCID58641415

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

Resolution of enantiomers of racemic 4-(5-chloro-2-fluorophenyl)-2-(3-hydroxyphenyl)-1-(2-methylalanyl)-2,5-dihydro-1H-pyrrole (3-4) by chiral normal-phase BPLC (Chiralcel OD column: 0.1% diethylamine in 10% ethanol in hexanes initially, grading to 30% ethanol in hexanes) provided (2S)-4-(5-chloro-2-fluorophenyl)-2(3-hydoxyphenyl)-1-(2-methylalanyl)-2,5-dihydro-1H-pyrrole (3-5) as the first eluting, minus (−) enantiomer.