5-Aminoquinoline → HCID 21948845, compound

HRID 2054927Notes

Reaction equation

HRID 2054927 reaction equation
[CH3:1][C:2]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:11])[CH2:3][C:4]1([C:7]([F:10])([F:9])[F:8])[CH2:6][O:5]1.[NH2:18][C:19]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:20]=1[CH:21]=[CH:22][CH:23]=[N:24]2>CCCCCC.C(OCC)(=O)C>[N:24]1[C:25]2[C:20](=[C:19]([NH:18][CH2:6][C:4]([C:7]([F:10])([F:9])[F:8])([OH:5])[CH2:3][C:2]([CH3:11])([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH3:1])[CH:28]=[CH:27][CH:26]=2)[CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 2

HCID 119115-AminoquinolineHCID 21948855HCID 21948855, compound

Product 1

HCID 21948845HCID 21948845, compoundYield 17.9%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Analogously to Example 1, 300 mg (1.22 mmol) of 2-(2-methyl-2-phenylpropyl)-2-(trifluoromethyl)oxirane and 882 mg (6.12 mmol) of 5-aminoquinoline are reacted. After chromatography on silica gel with hexane-ethyl acetate (0-75%), 85 mg of product is obtained.

Sources & evidence

ORD record
ord-2ba6ec003b12487e991680302b028283
Source dataset
uspto-grants-2008_02
Patent number
US07329753B2

Reaction notes

Loading…