反应详情

450 mg (2.2 mmol) of 2-chloro-5-nitroquinoline, 10 ml of 25% ammonia water and 10 ml of THF are stirred in a pressure vessel for 8 hours at 120° C. The batch is diluted with NaCl solution and extracted with ethyl acetate. The combined organic phases are dried (Na2SO4) and concentrated by evaporation: 370 mg of product.

1. extractionextracted with ethyl acetate
2. dry with materialThe combined organic phases are dried (Na2SO4)
3. concentrationconcentrated by evaporation