反应详情

温度

40 °C

840 mg (4.16 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester is dissolved in 70 ml of a 7N methanolic ammonia solution. It is stirred for 3.5 hours at 40° C., then for 20 hours at room temperature. After the solvent is removed in a vacuum, the purification is carried out on silica gel with hexane-ethyl acetate (0-100%) as well as with ethyl acetate-methanol (0-10%). 690 mg (88% of theory) of the product is obtained.

1. waitfor 20 hours at room temperature
2. customAfter the solvent is removed in a vacuum
3. customthe purification
4. custom690 mg (88% of theory) of the product is obtained