HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2054954Generated: November 2, 2026
Ammonia → 5-Aminoquinoline-2-carboxylic acid amide
https://huagongshe.com/reaction/2054954
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 5-aminoquinoline-2-carboxylate | HCID 45089604 | — |
| Product | 5-Aminoquinoline-2-carboxylic acid amide | HCID 69203614 | — |
Reaction Steps
840 mg (4.16 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester is dissolved in 70 ml of a 7N methanolic ammonia solution. It is stirred for 3.5 hours at 40° C., then for 20 hours at room temperature. After the solvent is removed in a vacuum, the purification is carried out on silica gel with hexane-ethyl acetate (0-100%) as well as with ethyl acetate-methanol (0-10%). 690 mg (88% of theory) of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07329753B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-a1989b4824354b65ae801f37622e36cc |
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| Source note | uspto-grants-2008_02 |
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