反应详情

76 mg (0.376 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester is dissolved with 10 ml of a 2.0 M methanolic methylamine solution. After 90 minutes under reflux and another 16 hours at room temperature, the solvent is removed under reduced pressure, and the residue is purified on silica gel with hexane-ethyl acetate (0-80%). 72 mg (95% of theory) of the product is obtained.

1. customthe solvent is removed under reduced pressure
2. customthe residue is purified on silica gel with hexane-ethyl acetate (0-80%)
3. custom72 mg (95% of theory) of the product is obtained