Methylamine → HCID 21948911, compound

HRID 2054986Notes

Reaction equation

HRID 2054986 reaction equation
CO[C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)=[O:4].[CH3:16][NH2:17]>>[CH3:16][NH:17][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:15])[N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 45089604Methyl 5-aminoquinoline-2-carboxylate

Product 1

HCID 21948911HCID 21948911, compound

Procedure

76 mg (0.376 mmol) of 5-aminoquinoline-2-carboxylic acid methyl ester is dissolved with 10 ml of a 2.0 M methanolic methylamine solution. After 90 minutes under reflux and another 16 hours at room temperature, the solvent is removed under reduced pressure, and the residue is purified on silica gel with hexane-ethyl acetate (0-80%). 72 mg (95% of theory) of the product is obtained.

Workup

  1. customthe solvent is removed under reduced pressure
  2. customthe residue is purified on silica gel with hexane-ethyl acetate (0-80%)
  3. custom72 mg (95% of theory) of the product is obtained

Sources & evidence

ORD record
ord-190b2443319d4cdd99f5ad69883aa279
Source dataset
uspto-grants-2008_02
Patent number
US07329753B2

Reaction notes

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