反应详情

A solution of tert-butyl 3-({3-(benzyloxy)-5-[(1S)-2-methoxy-1-methylethoxy]benzoyl}amino)-1H-pyrazole-1-carboxylate (23 g, 47.8 mmol) in THF (140 mL) and ethanol (140 mL) was evacuated and purged with nitrogen (×3). 10% Palladium on carbon (2.3 g, 10% w/w) was added and reaction mixture was evacuated and finally purged with hydrogen gas. Reaction mixture was left to stir at ambient temperature under a hydrogen balloon for 16-hours. Pd/C was filtered through diatomaceous earth and the filtrate concentrated in vacuo to give a white, foam (18 g, 97%).

1. custompurged with nitrogen (×3)
2. addition10% Palladium on carbon (2.3 g, 10% w/w) was added
3. customreaction mixture
4. customwas evacuated
5. customfinally purged with hydrogen gas
6. customReaction mixture
7. waitwas left
8. filtrationPd/C was filtered through diatomaceous earth
9. concentrationthe filtrate concentrated in vacuo