HRID2055001

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(F)cc1C(C)(C)CC(O)(C=O)C(F)(F)F

HCID11573122

未命名化合物

HCID69203919

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)C(=O)c1ccc2c(N=CC(O)(CC(C)(C)c3cc(F)ccc3OC)C(F)(F)F)cccc2n1

HCID69205171

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23963

Titanium

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution that consists of 210 mg (0.86 mmol) of 5-aminoquinoline-2-carboxylic acid diethylamide, 266 mg (0.86 mmol) of 4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal and 0.36 ml (1.73 mmol) of titanium tetraethylate in 15 ml of tetrahydrofuran is stirred for one hour at room temperature and then for 3 hours at 80° C. After removal of the solvent and purification on silica gel with hexane-ethyl acetate (0-70%), 230 mg (52% of theory) of the product is obtained.

WORKUP

后处理

waitfor 3 hours at 80° C
customAfter removal of the solvent and purification on silica gel with hexane-ethyl acetate (0-70%), 230 mg (52% of theory) of the product
customis obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f30610b849c84685a97eb0566d573476
来源数据集: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07329753B2
来源说明: uspto-grants-2008_02

反应 SMILES

[CH2:1]([N:3]([CH2:17][CH3:18])[C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[NH2:16])[N:7]=1)=[O:5])[CH3:2].[F:19][C:20]1[CH:21]=[CH:22][C:23]([O:38][CH3:39])=[C:24]([C:26]([CH3:37])([CH3:36])[CH2:27][C:28]([OH:35])([C:31]([F:34])([F:33])[F:32])[CH:29]=O)[CH:25]=1>O1CCCC1.[Ti]>[CH2:17]([N:3]([CH2:1][CH3:2])[C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[N:16]=[CH:29][C:28]([OH:35])([C:31]([F:32])([F:34])[F:33])[CH2:27][C:26]([C:24]2[CH:25]=[C:20]([F:19])[CH:21]=[CH:22][C:23]=2[O:38][CH3:39])([CH3:36])[CH3:37])[N:7]=1)=[O:5])[CH3:18]