Triethylamine → HCID 131726772, compound

HRID 2055216Notes

Reaction equation

HRID 2055216 reaction equation
Cl.Cl.[Cl:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1.C(N(CC)CC)C.[Cl:24][CH2:25][C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:27]>C(O)C>[ClH:3].[ClH:24].[Cl:3][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH2:25][C:26]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[O:27])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 107572-ChloroacetophenoneHCID 20437426HCID 20437426, compound

Product 1

HCID 131726772HCID 131726772, compoundYield 129.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-(4-chlorobenzyl)piperazine dihydrochloride (5 g, 20 mmol), triethylamine (5.58 ml, 40 mmol) and 2-chloro-1-phenylethanone (4.08 g, 26 mmol) in 40 ml of anhydrous ethanol was refluxed for 8 hours, and then treated according to general preparation 2 to give 5.2 g of compound (IV-3), yield 59.51%, mp 256-258° C. M+ 328.

Workup

  1. temperaturewas refluxed for 8 hours
  2. additiontreated
  3. customaccording to general preparation 2

Sources & evidence

ORD record
ord-e0807f3f702d45a3935bb356b0dd2f8c
Source dataset
uspto-grants-2008_02
Patent number
US07332495B2

Reaction notes

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