HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N1-benzyl-N4-(4-chloro phenacyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | p-Chlorophenacyl bromide | HCID 68303 | — |
| Reactant | Piperazine, 1-(phenylmethyl)-, hydrochloride (1:2) | HCID 12198046 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N1-benzyl-N4-(4-chloro phenacyl)piperazine dihydrochloride | HCID 69061709 | 114.5% |
Reaction Steps
A mixture of N-benzyl piperazine dihydrochloride (2.49 g, 10 mmol), K2CO3 (4.14 g, 30 mmol) and 2-bromo-1-(4-chlorophenyl)ethanone (2.8 g, 12 mmol) in 100 ml of acetone was refluxed for 5 hours, and then treated according to general preparation 2 to give 2.76 g of compound (IV-6), yield 68.7%, mp 231-233° C. M+ 328.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332495B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-890bc28bf526482fb3d55df421f76725 |
| Source note | uspto-grants-2008_02 |