2-Chloroacetophenone → N1-(4-nitrobenzyl)-N4-phenacyl piperazine dihydrochloride

HRID 2055220노트

반응식

HRID 2055220 반응식
[ClH:1].Cl.[N+:3]([C:6]1[CH:18]=[CH:17][C:9]([CH2:10][N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:8][CH:7]=1)([O-:5])=[O:4].[Cl:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:22].C([O-])([O-])=O.[K+].[K+]>>[ClH:19].[ClH:1].[N+:3]([C:6]1[CH:18]=[CH:17][C:9]([CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH2:20][C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)=[O:22])[CH2:13][CH2:12]2)=[CH:8][CH:7]=1)([O-:5])=[O:4]

참가 물질

4

반응물 3

HCID 107572-ChloroacetophenoneHCID 11430Potassium CarbonateHCID 180056791-(4-Nitrobenzyl)piperazine dihydrochloride

생성물 1

HCID 86606197N1-(4-nitrobenzyl)-N4-phenacyl piperazine dihydrochloride수율 75%

실험 절차

A mixture of N-(4-nitrobenzyl)piperazine dihydrochloride (10 g, 34 mmol), 2-chloro-1-phenylethanone (5.80 g, 37 mmol) and anhydrous K2CO3 (16.5 g, 119 mmol) was treated according to general preparation 2 to give 10.51 g of N1-(4-nitrobenzyl)-N4-phenacyl piperazine dihydrochloride (A), yield 75%, mp 236-8° C.

후처리

  1. additionwas treated
  2. customaccording to general preparation 2

출처 및 근거

ORD 기록
ord-d30646047ce841d2861bb56e6f241677
출처 데이터셋
uspto-grants-2008_02
특허 번호
US07332495B2

반응 노트

불러오는 중…