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2-Chloroacetophenone → N1-(4-nitrobenzyl)-N4-phenacyl piperazine dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloroacetophenone | HCID 10757 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(4-Nitrobenzyl)piperazine dihydrochloride | HCID 18005679 | — |
| 生成物 | N1-(4-nitrobenzyl)-N4-phenacyl piperazine dihydrochloride | HCID 86606197 | 75% |
反応手順
A mixture of N-(4-nitrobenzyl)piperazine dihydrochloride (10 g, 34 mmol), 2-chloro-1-phenylethanone (5.80 g, 37 mmol) and anhydrous K2CO3 (16.5 g, 119 mmol) was treated according to general preparation 2 to give 10.51 g of N1-(4-nitrobenzyl)-N4-phenacyl piperazine dihydrochloride (A), yield 75%, mp 236-8° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07332495B2 |
| 出典データセット | uspto-grants-2008_02 |
| ORD ID | ord-d30646047ce841d2861bb56e6f241677 |
| 出典メモ | uspto-grants-2008_02 |