HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4'-Chloroacetyl(acetanilide) → N1-(4-nitrobenzyl)-N4-[(4-acetamido)phenacyl]piperazine dihydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4'-Chloroacetyl(acetanilide) | HCID 8805 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 1-(4-Nitrobenzyl)piperazine dihydrochloride | HCID 18005679 | — |
| Produkt | N1-(4-nitrobenzyl)-N4-[(4-acetamido)phenacyl]piperazine dihydrochloride | HCID 69055552 | 74% |
Reaktionsschritte
A mixture of N-(4-nitrobenzyl)piperazine dihydrochloride (2.94 g, 10 mmol), N-[4-(2-chloroacetyl)phenyl]acetamide (2.37 g, 12 mmol) and anhydrous K2CO3 (4.83 g, 35 mmol) was treated according to general preparation 2 to give compound (IV-18), yield 74%, mp 228-230° C. M+ 396.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07332495B2 |
| Quelldatensatz | uspto-grants-2008_02 |
| ORD ID | ord-65e0a3f8c5474fbca21d3a8790b9e5ef |
| Quellennotiz | uspto-grants-2008_02 |