HRID2055233

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID12828501

未命名化合物

HCID13699429

2-Bromo-1-(5-chloro-6-methoxy-2-naphthalenyl)-1-propanone

C14H12BrClO2

PRODUCTS

生成物

结构：COc1cc(CN2CCN(C(C)C(=O)c3ccc4c(Cl)c(OC)ccc4c3)CC2)cc(OC)c1OC.Cl.Cl

HCID69202709

未命名化合物

收率 122.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A mixture of N1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (0.9 g, 2.7 mmol), 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (1.05 g, 3.2 mmol) and K2CO3 (1.3 g, 9.5 mmol) in 25 ml of DMF was treated according to general preparation 2 to give 1.15 g of compound (IV-34), yield 72.7%, mp 219-222° C., M+ 512.

WORKUP

后处理

additionwas treated
customaccording to general preparation 2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7c9456dd082b4764b483d37fa3c2ed0d
来源数据集: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07332495B2
来源说明: uspto-grants-2008_02

反应 SMILES

[ClH:1].Cl.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:15]=[C:16]([O:20][CH3:21])[C:17]=1[O:18][CH3:19])[CH2:8][N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.Br[CH:23]([CH3:39])[C:24]([C:26]1[CH:35]=[CH:34][C:33]2[C:28](=[CH:29][CH:30]=[C:31]([O:37][CH3:38])[C:32]=2[Cl:36])[CH:27]=1)=[O:25].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:36].[ClH:1].[CH3:21][O:20][C:16]1[CH:15]=[C:7]([CH:6]=[C:5]([O:4][CH3:3])[C:17]=1[O:18][CH3:19])[CH2:8][N:9]1[CH2:14][CH2:13][N:12]([CH:23]([C:24]([C:26]2[CH:35]=[CH:34][C:33]3[C:28](=[CH:29][CH:30]=[C:31]([O:37][CH3:38])[C:32]=3[Cl:36])[CH:27]=2)=[O:25])[CH3:39])[CH2:11][CH2:10]1