HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N1-(3,4,5-trimethoxybenzyl)-N4-[1-(5-chloro-6-methoxy-2-naphthoyl) ethyl]piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-[(3,4,5-Trimethoxyphenyl)methyl]piperazine;dihydrochloride | HCID 12828501 | — |
| Reactant | 2-Bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one | HCID 13699429 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N1-(3,4,5-trimethoxybenzyl)-N4-[1-(5-chloro-6-methoxy-2-naphthoyl) ethyl]piperazine dihydrochloride | HCID 69202709 | 122.7% |
Reaction Steps
A mixture of N1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (0.9 g, 2.7 mmol), 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (1.05 g, 3.2 mmol) and K2CO3 (1.3 g, 9.5 mmol) in 25 ml of DMF was treated according to general preparation 2 to give 1.15 g of compound (IV-34), yield 72.7%, mp 219-222° C., M+ 512.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332495B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-7c9456dd082b4764b483d37fa3c2ed0d |
| Source note | uspto-grants-2008_02 |