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HRID2055235

反应详情

EQUATION

反应方程式

HRID 2055235 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COc1ccc2cc(C(=O)C(C)Br)ccc2c1Cl
HCID13699429

2-Bromo-1-(5-chloro-6-methoxy-2-naphthalenyl)-1-propanone

C14H12BrClO2

结构：Cl.Cl.Clc1cccc(CN2CCNCC2)c1
HCID44889868

1-[(3-Chlorophenyl)methyl]piperazine--hydrogen chloride (1/2)

C11H17Cl3N2

PRODUCTS

生成物

1
结构：COc1ccc2cc(C(=O)C(C)N3CCN(Cc4cccc(Cl)c4)CC3)ccc2c1Cl.Cl.Cl
HCID69204301

未命名化合物

收率 124.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A mixture of N-(3-chlorobenzyl)piperazine dihydrochloride (1.35 g, 5 mmol), 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (1.96 g, 6 mmol) and K2CO3 (2.42 g, 17.5 mmol) in 40 ml of DMF was treated according to general preparation 2 to give 1.65 g of compound (IV-36), yield 64%. M+ 444.

WORKUP

后处理

  1. additionwas treated
  2. customaccording to general preparation 2