HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N1-(3-chlorobenzyl)-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl]piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one | HCID 13699429 | — |
| Reactant | 1-(3-Chloro-benzyl)-piperazine dihydrochloride | HCID 44889868 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N1-(3-chlorobenzyl)-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl]piperazine dihydrochloride | HCID 69204301 | 124.5% |
Reaction Steps
A mixture of N-(3-chlorobenzyl)piperazine dihydrochloride (1.35 g, 5 mmol), 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (1.96 g, 6 mmol) and K2CO3 (2.42 g, 17.5 mmol) in 40 ml of DMF was treated according to general preparation 2 to give 1.65 g of compound (IV-36), yield 64%. M+ 444.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332495B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-213a68e757654f27a222f113248611ea |
| Source note | uspto-grants-2008_02 |