HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N1-phenylethyl-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl]piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one | HCID 13699429 | — |
| Reactant | 1-(1-Phenylethyl)piperazine dihydrochloride | HCID 21537791 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N1-phenylethyl-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl]piperazine dihydrochloride | HCID 69200998 | 83.2% |
Reaction Steps
A mixture of N-(1-phenylethyl)piperazine dihydrochloride (0.79 g, 3 mmol), 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (1.64 g, 5 mmol) and K2CO3 (1.38 g, 10 mmol) in acetone was treated according to general preparation 2 to give 1.06 g of compound (IV-43) as white solid, yield 65%, mp 231-232° C. M+ 437.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07332495B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-b659ff3691324a908216390347bb4589 |
| Source note | uspto-grants-2008_02 |